| Identification | Back Directory | [Name]
Pyridazine N-oxide | [CAS]
1457-42-7 | [Synonyms]
PYRIDAZINE-N-OXIDE
Pyridazine 1-oxide
Pyridazine N-oxide 97%
1-oxidopyridazin-1-ium
Pyridazine N-oxide ISO 9001：2015 REACH
4-chlorine-5-Mi oxide pyridazine -3(2H)-ketone | [EINECS(EC#)]
200-001-2 | [Molecular Formula]
C4H4N2O | [MDL Number]
MFCD05742416 | [MOL File]
1457-42-7.mol | [Molecular Weight]
96.09 |
| Hazard Information | Back Directory | [Uses]
Coupling partner in Pd-catalyzed direct arylation reactions. | [Synthesis]
Pyridazine N-oxide was prepared as follows: appropriate diazine (1 eq.) and mCPBA (1 eq.) were dissolved in DCM (0.2 M). The reaction was stirred for 16 hours. PPh3 (0.5 eq.) was then added to reduce any unreacted peracid and the mixture was stirred for a | [Purification Methods]
Purify the oxide by distillation in a vacuum and by sublimation in vacuo. When a solution of the oxide in MeOH is treated with an aqueous solution of CuCl2, the [C4H4N2O]2—CuCl2-2H2O-complex (m 182-183o) is formed from which the oxide can be recovered . [Pollak et al. J Org Chem 35 2478 1970, Klinge et al. Recl Trav Chim, Pays Bas 95 21 1976, Ohsawa et al. Tetrahedron Lett 1979 1978, Koelsch & Gumprecht J Org Chem 23 1605 1958, Beilstein 23 III/IV 890.] |
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