| Identification | Back Directory | [Name]
6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid | [CAS]
145739-56-6 | [Synonyms]
TETOMILAST
-(4-hydroxyphenyl)acrylaldehyde
6-(2-(3,4-diethoxyphenyl)thiazol-4-yl)picolinic acid
2-Pyridinecarboxylic acid, 6-[2-(3,4-diethoxyphenyl)-4-thiazolyl]-
6-[2-(3,4-diethoxyphenyl)-thiazole-4-yl]pyridine-2-carboxylic acid
6-[2-(3,4-Diethoxy-phenyl)-thiazol-4-yl]-pyridine-2-carboxylic acid
6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid | [Molecular Formula]
C19H18N2O4S | [MOL File]
145739-56-6.mol | [Molecular Weight]
370.42 |
| Chemical Properties | Back Directory | [Boiling point ]
598.6±60.0 °C(Predicted) | [density ]
1.279±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Solid | [pka]
3.28±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Tetomilast (OPC-6535) is a PDE4 inhibitor with potential for the research of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). | [IC 50]
PDE4 | [References]
[1] Ichikawa H, Okamoto S, Kamada N, et al. Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice. Inflamm Bowel Dis. 2008;14(11):1483-1490. DOI:10.1002/ibd.20524 |
|
| Company Name: |
Heterochem
|
| Tel: |
027-88041443 13072715837 |
| Website: |
www.hetero-chem.com |
| Company Name: |
BePharm Ltd
|
| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
|