| Identification | Back Directory | [Name]
4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE | [CAS]
145783-14-8 | [Synonyms]
EOS-61674
Ticagrelor-28
thio)pyrimidine
oro-5-nitro-2-(propyL
4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDI
4,6-Dichloro-5-nitro-2-propylthiopyridine
4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE
4,6-Dichloro-5-nitro-2-(propythio)pyrimidine
PyriMidine, 4,6-dichloro-5-nitro-2-(propylthio)-
4,6-dichloro-5-nitro-2-(propylsulfanyl)pyriMidine
4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE 145783-14-8
4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE ISO 9001：2015 REACH
4,6-dichloro-5-nitro-2-(propylsulfanyl)pyriMidine
4,6-dichloro-5-nitro-2-(propylsulfanyl)pyriMidine | [EINECS(EC#)]
700-475-0 | [Molecular Formula]
C7H7Cl2N3O2S | [MDL Number]
MFCD10698669 | [MOL File]
145783-14-8.mol | [Molecular Weight]
268.12 |
| Chemical Properties | Back Directory | [Boiling point ]
377.8±37.0 °C(Predicted) | [density ]
1.54±0.1 g/cm3(Predicted) | [vapor pressure ]
0.005Pa at 25℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Sparingly), DMSO (Sparingly), Ethyl Acetate (Slightly) | [form ]
Oil | [pka]
-8.48±0.50(Predicted) | [color ]
Colourless to Dark Yellow | [Stability:]
Unstable in DMSO Solution | [InChI]
InChI=1S/C7H7Cl2N3O2S/c1-2-3-15-7-10-5(8)4(12(13)14)6(9)11-7/h2-3H2,1H3 | [InChIKey]
DDEDQHVHVPJFAC-UHFFFAOYSA-N | [SMILES]
C1(SCCC)=NC(Cl)=C([N+]([O-])=O)C(Cl)=N1 | [LogP]
2.6 at 25℃ and pH7.3 | [Surface tension]
70.5-71.7mN/m at 9.1mg/L and 25℃ |
| Hazard Information | Back Directory | [Chemical Properties]
4,6-Dichloro-5-nitro-2-propylthiopyrimidine is colorless or yellow oil liquid at room temperature and pressure, solubility in dichloromethane, chloroform, dimethyl sulfoxide, ethyl acetate is general, and insoluble in water, and dissolved in dimethyl sulfoxide is easy to deteriorate. | [Uses]
4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine is used as a reactnat in the synthesis of carba-nucleosides as potent antagonists of ADP purinergic receptor P2Y12 on human platelets. | [Synthesis]
N,N-dimethylaniline (104.8 g, 0.86 mol) was added to a mixture of 5-nitro-2-(propylthio)pyrimidine-4,6-diol (100.0 g, 0.43 mol) and phosphinic acid chloride (238.71 g, 1.55 mol) at zero degrees C. The mixture was heated at 100-110 °C and kept at this t |
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