| Identification | Back Directory | [Name]
CHR 6494 trifluoroacetate | [CAS]
1458630-17-5 | [Synonyms]
CHR 6494 TFA
CHR 6494 trifluoroacetate
3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate
3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine 2,2,2-trifluoroacetate
CHR-6494,inhibit,apoptosis,Haspin Kinase,NRAS mutant melanoma cells,CHR 6494,mitotic catastrophe,Inhibitor,mice,CHR6494,cancer cells,CHR6494 TFA,BRAFV600E mutant melanoma cells,CHR 6494 TFA | [Molecular Formula]
C18H17F3N6O2 | [MDL Number]
MFCD24849399 | [MOL File]
1458630-17-5.mol | [Molecular Weight]
406.362 |
| Hazard Information | Back Directory | [Uses]
CHR6494 is a small-molecule inhibitor of histone kinase haspin, with a wide spectrum of anticancer effects. | [in vivo]
CHR-6494 (TFA; 50 mg/kg; i.p. in two cycles of five consecutive days for 15 days) inhibits the growth of tumor in nude mice bearing HCT-116 human colorectal cancer cells[1].
CHR-6494 (TFA; 20 mg/kg; intraperitoneal injection for 15 consecutive days) inhibits the tumor growth in nude mice bearing MDA-MB-231 xenograft tumors[3].
| Animal Model: | Male 4-5 weeks old athymic nu/nu mice harboring HCT-116 cells xenograft tumor with a tumor volume of 200?mm3[1] | | Dosage: | 50?mg/kg (diluted in a solution of 10% DMSO/20% 2-hydroxypropyl-b-cyclodextrin) | | Administration: | i.p. in two cycles of five consecutive days for 15 days | | Result: | Dose-dependent tumor growth inhibition was demonstrated.
Did not change the body weight of mice.
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| Animal Model: | 4‐week‐old female nude mice bearing MDA-MB-231 xenograft tumors | | Dosage: | 20 mg/kg in a final formulation in 10% DMSO/20% 2‐hydroxypropyl‐β‐cyclodextrin | | Administration: | i.p. for 15 consecutive days | | Result: | Inhibited the tumor volume and weight compared with the control group in nude mice bearing MDA-MB-231 xenograft tumors.
Enhanced the tumor volume and weight inhibition of MLN8237 (20 mg/kg; p.o.) in vivo.
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| [IC 50]
haspin: 2 nM (IC50) | [storage]
Store at +4°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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