| Identification | Back Directory | [Name]
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- | [CAS]
1458674-25-3 | [Synonyms]
IMP-1700
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]- | [Molecular Formula]
C25H22F4N4O3S | [MOL File]
1458674-25-3.mol | [Molecular Weight]
534.53 |
| Chemical Properties | Back Directory | [Boiling point ]
677.3±65.0 °C(Predicted) | [density ]
1.564±0.06 g/cm3(Predicted) | [storage temp. ]
-20° | [solubility ]
Soluble in DMSO (up to 25 mg/ml). | [form ]
solid | [pka]
6.44±0.41(Predicted) | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
IMP-1700 (1458674-25-3) is a potent inhibitor of the bacterial DNA double-strand break repair complex AddAB. It is capable of synergistic sensitization of methicillin-resistant staphylococcus aureus (MRSA) to ciprofloxacin (EC50?= 0.6nM).? IMP-1700 is an important new tool for exploring new treatment options for drug resistant bacteria. | [Uses]
IMP-1700 is an important tool for exploring new treatment options for drug resistant bacteria. A potent inhibitor of the bacterial DNA double-strand break repair complex AddAB. | [storage]
-20°C | [References]
1) Lim?et al.?(2019),?Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus; Bioorg. Med. Chem.,?27?114962 |
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| Company Name: |
ChemeGen
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| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
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