| Identification | Back Directory | [Name]
(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One | [CAS]
145888-79-5 | [Synonyms]
RAMB4
PTP1B-IN-9?
(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One
4-Piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]-
(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One(WXC02309) | [Molecular Formula]
C19H13Cl4NO | [MOL File]
145888-79-5.mol | [Molecular Weight]
413.12 |
| Chemical Properties | Back Directory | [Boiling point ]
607.5±55.0 °C(Predicted) | [density ]
1.463±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO: 5 mg/mL (12.10 mM) | [form ]
A solid | [pka]
6.43±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity[1]. | [References]
[1] Anchoori RK, et al. Stressing?the?ubiquitin-proteasome?system?without?20S?proteolytic?inhibition?selectively?kills?cervical?cancer?cells.PLoS One.?2011;6(8):e23888. DOI:10.1371/journal.pone.0023888 |
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Wuxi AppTec
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Bide Pharmatech Ltd.
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https://www.bidepharm.com/ |
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InvivoChem
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