| Hazard Information | Back Directory | [Description]
BO 2367 is a topoisomerase inhibitor with applications to tumor growth suppression. | [Uses]
(-)-BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-)-BO 2367 shows IC50 values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-)-BO 2367 is a potent antitumor agent[1]. | [IC 50]
Topoisomerase II | [References]
[1] T Yoshinari, et al. Stereo (C7)-dependent topoisomerase II inhibition and tumor growth suppression by a new quinolone, BO-2367. Jpn J Cancer Res. 1993 Jul;84(7):800-6. DOI:10.1111/j.1349-7006.1993.tb02047.x |
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CHEMICAL LAND21
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www.chemicalland21.com |
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