| Identification | Back Directory | [Name]
K201 hemifumarate | [CAS]
145903-06-6 | [Synonyms]
JTV-519
(K201
K201 free base
JTV-519 free base
K201 hemifumarate
JTV-519 hemifumarate
4-[3-(4-Benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine
1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
1-Propanone, 1-(2,3-dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-
1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone hemifumarate
3-(4-benzylpiperidin-1-yl)-1-(7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)propan-1-one(K201 hemifumarate) | [Molecular Formula]
C25H32N2O2S | [MDL Number]
MFCD23098915 | [MOL File]
145903-06-6.mol | [Molecular Weight]
424.6 |
| Chemical Properties | Back Directory | [Boiling point ]
615.1±55.0 °C(Predicted) | [density ]
1.153±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
8.93±0.10(Predicted) | [color ]
white to beige | [BRN ]
10598851 | [InChIKey]
MNAIJOCDPCXVEY-WXXKFALUSA-N | [SMILES]
OC(=O)\C=C\C(O)=O.COc1ccc2SCCN(Cc2c1)C(=O)CCN3CCC(CC3)Cc4ccccc4.COc5ccc6SCCN(Cc6c5)C(=O)CCN7CCC(CC7)Cc8ccccc8 |
| Safety Data | Back Directory | [Hazard Codes ]
N,Xn | [Risk Statements ]
50/53-53-22 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
JTV-519 is a potent inhibitor or the ryanodine receptor 2 (RYR2) blocker. RYR2 is a cardiac calcium channel that regulates calcium levels in the sarcoplasmic reticulum. JTV-519 stabilizes RYR2 in the closed state. |
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