| Chemical Properties | Back Directory | [Melting point ]
185-187 °C | [Boiling point ]
449.2±45.0 °C(predicted) | [density ]
1.457±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
8.17±0.35(predicted) |
| Hazard Information | Back Directory | [Uses]
PfFAS-II inhibitor 1 (Compound 3) is a Plasmodium falciparum type II fatty acid biosynthesis pathway (PfFAS-II) inhibitor, with an IC50 of 0.63 μM for PfFabI enzyme. PfFAS-II inhibitor 1 has antimalarial activity[1]. | [References]
[1] Belluti F, et al. Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). J Med Chem. 2013 Oct 10;56(19):7516-26. DOI:10.1021/jm400637m |
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