| Identification | Back Directory | [Name]
BM 212 | [CAS]
146204-42-4 | [Synonyms]
BM 212
BM 212;BM-212
1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine
Piperazine, 1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl- | [Molecular Formula]
C23H25Cl2N3 | [MDL Number]
MFCD30489752 | [MOL File]
146204-42-4.mol | [Molecular Weight]
414.37 |
| Chemical Properties | Back Directory | [Boiling point ]
528.3±50.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:0.75(Max Conc. mg/mL);1.81(Max Conc. mM)
Ethanol:3.03(Max Conc. mg/mL);7.31(Max Conc. mM) | [form ]
A crystalline solid | [pka]
7.60±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 μM[1][2]. | [References]
[1] Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. DOI:10.1128/AAC.42.11.3035
[2] Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) DOI:10.1371/journal.pone.0056980
[3] Albertus Viljoen, et al. Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria. Nanoscale Horiz. 2020 Jun 1;5(6):944-953. DOI:10.1039/c9nh00736a
[4] Delia Deidda, et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. DOI:10.1128/AAC.42.11.3035 |
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Musechem
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www.musechem.com |
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Twochem Co.Ltd.
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