| Identification | Back Directory | [Name]
HS-345 | [CAS]
1462329-41-4 | [Synonyms]
HS-345
3-Pyridinesulfonamide, 2-amino-N,N-dimethyl-5-[3-(4-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]- | [Molecular Formula]
C19H18N6O2S | [MOL File]
1462329-41-4.mol | [Molecular Weight]
394.45 |
| Hazard Information | Back Directory | [Uses]
HS-345 is a TrkA/Ak inhibitor with significant anti-pancreatic cancer effects. HS-345 inhibits the growth and proliferation of pancreatic cancer cells by targeting the TrkA/Akt signaling pathway, while also inducing apoptosis. Additionally, HS-345 suppresses blood vessel formation by decreasing the expression of HIF-1α and VEGF. HS-345 holds promise for research in pancreatic cancer[1]. | [IC 50]
TrkA | [References]
[1] Seo JH, et al. Anti-cancer effect of HS-345, a new tropomyosin-related kinase A inhibitor, on human pancreatic cancer. Cancer Lett. 2013 Sep 28;338(2):271-81. DOI:10.1016/j.canlet.2013.04.002 |
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