| Identification | Back Directory | [Name]
6-azido-1-Hexanol | [CAS]
146292-90-2 | [Synonyms]
Azido-C6-OH
6-N3-1-hexanol
6-azido-1-Hexanol
6-azidohexan-1-ol,6-Azido-1-hexanol | [Molecular Formula]
C6H13N3O | [MDL Number]
MFCD22577171 | [MOL File]
146292-90-2.mol | [Molecular Weight]
143.187 |
| Hazard Information | Back Directory | [Uses]
Azido-C6-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-C6-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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