| Identification | Back Directory | [Name]
2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]- | [CAS]
1466445-39-5 | [Synonyms]
EGFR-IN-40
2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]- | [Molecular Formula]
C23H20N6O3 | [MOL File]
1466445-39-5.mol | [Molecular Weight]
428.44 |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively[1]. | [IC 50]
BTK: 1.2 nM (IC50); EGFR: 5.3 nM (IC50); ITK: 46.1 nM (IC50) | [References]
[1] Dou Dou, et al. Discovery of Pteridine-7(8 H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK). J Med Chem. 2022 Feb 10;65(3):2694-2709. DOI:10.1021/acs.jmedchem.1c02208 |
|
|