| Identification | Back Directory | [Name]
1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) | [CAS]
146731-14-8 | [Synonyms]
Z-335 sodium
1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1) | [Molecular Formula]
C18H19ClNNaO4S | [MDL Number]
MFCD00941373 | [MOL File]
146731-14-8.mol | [Molecular Weight]
403.85 |
| Hazard Information | Back Directory | [Description]
Z-335 Salt is a thromboxane A2 receptor antagonist potentially for the treatment of arterial occlusive disease. | [Uses]
Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively[1][2]. | [in vivo]
Z-335 (0.3-3 mg/kg, p.o.) inhibits thrombus formation in a dose-dependent manner[2].
Z-335 (3 mg/kg, p.o.) significantly prevents thrombus formation even at 16 h [2].
| [References]
[1] T Tanaka, et al. Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist. Eur J Pharmacol. 1998 Sep 11;357(1):53-60. DOI:10.1016/s0014-2999(98)00540-8
[2] T Tanaka, et al. Z-335, a new thromboxane A(2) receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats. Eur J Pharmacol. 2000 Aug 11;401(3):413-8. DOI:10.1016/s0014-2999(00)00434-9 |
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