| Identification | Back Directory | [Name]
1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID | [CAS]
1469902-72-4 | [Synonyms]
Kv1.5IN4
Kv1.5INIV
COMPOUND 4
Kv1.5INIIII
Kv1.5-IN-IIII
Compound IIII
1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID | [Molecular Formula]
C19H18ClNO3 | [MDL Number]
MFCD03453282 | [MOL File]
1469902-72-4.mol | [Molecular Weight]
343.8 |
| Hazard Information | Back Directory | [Uses]
Kv1.5-IN-1 is a Kv1.5 channel inhibitor. Its target selectivity and pharmacodynamic effects were evaluated in an in vitro rat model. After the introduction of a methoxy group at the R5 position, Kv1.5-IN-1 showed inhibitory potency similar to that of the unsubstituted compound. Its IC50 value for hKv1.5 channels was 0.51 μM. Kv1.5-IN-1 exhibited a high degree of selectivity, nearly 2,600 times higher than compound Ik and 300 times higher than compound IId, indicating that it may be a safe inhibitor. Due to its good pharmacological behavior, Kv1.5-IN-1 deserves further pharmacodynamic and pharmacokinetic evaluation. These properties make Kv1.5-IN-1 a potential Kv1.5 channel inhibitor that may have application prospects in the treatment of related diseases. | [References]
[1] Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors |
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