| Identification | Back Directory | [Name]
mPGES1-IN-3 | [CAS]
1469976-70-2 | [Synonyms]
mPGES1-IN-3
mPGES1IN3,mPGES-1-IN-3,mPGES1 IN 3
1H-[1,4]Dioxino[2,3-e]benzimidazole-5-carboxamide, 2-[(2-chloro-6-fluorophenyl)amino]-N-[3-fluoro-5-(trifluoromethyl)phenyl]-7,8-dihydro-1-methyl- | [Molecular Formula]
C24H16ClF5N4O3 | [MDL Number]
MFCD30747869 | [MOL File]
1469976-70-2.mol | [Molecular Weight]
538.85 |
| Hazard Information | Back Directory | [Uses]
mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM)[1]. | [References]
[1] Muthukaman N, et al. Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 DOI:10.1016/j.bmcl.2016.10.079 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
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