147034-01-3

76008-76-9

147034-01-3

General procedure for the synthesis of 2,5-dibromobenzyl alcohol from the compound (CAS: 76008-76-9): sodium borohydride (33 g, 880 mmol) was slowly added to a stirred solution of ethyl 2,5-dibromobenzoate (90 g, 290 mmol) in ethanol (900 mL) at 0 °C. The reaction mixture was stirred at room temperature for 12 hours, followed by heating and refluxing for 20 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the residue, which was then extracted with ethyl acetate (EtOAc). The organic layers were combined and concentrated under reduced pressure to obtain the crude product. Finally, the crude product was purified by fast column chromatography to afford 35 g of 2,5-dibromobenzyl alcohol.