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147149-76-6

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147149-76-6 Structure

147149-76-6 Structure
IdentificationBack Directory
[Name]

Nolatrexed
[CAS]

147149-76-6
[Synonyms]

NOLA-012
NOLATREXED
Nolatrexed [inn]
2-Amino-6-methyl-5-(4-pyridylthio)-4(3H)-quinazolinone
4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-
[EINECS(EC#)]

1533716-785-6
[Molecular Formula]

C14H12N4OS
[MDL Number]

MFCD07781275
[MOL File]

147149-76-6.mol
[Molecular Weight]

284.34
Chemical PropertiesBack Directory
[Melting point ]

301-302°
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.
[References]

[1] Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride (AG337, THYMITAQ) administered orally for 5 days PMID:9918208
Spectrum DetailBack Directory
[Spectrum Detail]

Nolatrexed(147149-76-6)1HNMR
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