| Identification | Back Directory | [Name]
KT185 | [CAS]
1472640-86-0 | [Synonyms]
KT185
KT185 >=98% (HPLC)
Methanone, [4'-[1-[(2-phenyl-1-piperidinyl)carbonyl]-1H-1,2,3-triazol-4-yl][1,1'-biphenyl]-3-yl]-1-piperidinyl- | [Molecular Formula]
C32H33N5O2 | [MDL Number]
MFCD28580128 | [MOL File]
1472640-86-0.mol | [Molecular Weight]
519.64 |
| Chemical Properties | Back Directory | [Boiling point ]
763.0±70.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF:30.0(Max Conc. mg/mL);57.73(Max Conc. mM)
DMSO:65.0(Max Conc. mg/mL);125.08(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);57.73(Max Conc. mM) | [form ]
A crystalline solid | [pka]
-1.20±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
KT185 is an orally-bioavailable, brain-penetrant and selective ABHD6 inhibitor, with an IC50 0.21 nM in Neuro2A cells[1]. | [Biological Activity]
KT185 is a very potentselective inhibitor of a/b-Hydrolase Domain Containing 6 (ABHD6). The compond KT185 is orally bioavailable and inhibits ABHD6 activity in the brain and liver of mice. | [References]
[1] Hsu KL, et al. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). J Med Chem. 2013 Nov 14;56(21):8270-9. DOI:10.1021/jm400899c |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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