| Identification | Back Directory | [Name]
3',4'-DiMethoxy-α-naphthoflavone | [CAS]
14756-24-2 | [Synonyms]
DiMNF
NSC 123391
3',4'-DiMethoxy-α-naphthoflavone
3',4'-DiMethoxy-α-naphthoflavone
2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one
2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
4H-Naphtho[1,2-b]pyran-4-one, 2-(3,4-dimethoxyphenyl)- | [Molecular Formula]
C21H16O4 | [MDL Number]
MFCD00143008 | [MOL File]
14756-24-2.mol | [Molecular Weight]
332.35 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥13mg/mL | [form ]
powder | [color ]
white to tan | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1?DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2?Represses estrogen-inducible transcription.3 | [Uses]
3'',4''-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation. | [Uses]
3',4'-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation. | [References]
1) Murray?et al. (2011),?Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone;? Mol. Pharmacol.,?79?508
2) Narayanan?et al. (2012),?Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure;? J. Pharmacol. Exp. Ther.,?342?345
3) Labrecque?et al. (2012),?Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines;? PLoS One,?7(1)?e29545 |
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BOC Sciences
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https://www.bocsci.com |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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