| Identification | Back Directory | [Name]
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol | [CAS]
147591-46-6 | [Synonyms]
ID 8
CS-989
ID 8; ID8
ID 8 free base
1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro-
1-(4-methoxy-phenyl)-2-methyl-3-nitro-1H-indole-6-ol
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol ID8 | [Molecular Formula]
C16H14N2O4 | [MDL Number]
MFCD00593367 | [MOL File]
147591-46-6.mol | [Molecular Weight]
298.293 |
| Chemical Properties | Back Directory | [Melting point ]
266 °C(dec.) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
powder | [color ]
yellow | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | [InChI]
1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3 | [InChIKey]
VVZNWYXIOADGSW-UHFFFAOYSA-N | [SMILES]
COc1ccc(cc1)-n2c(C)c([N+]([O-])=O)c3ccc(O)cc23 |
| Hazard Information | Back Directory | [Description]
ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2 | [Uses]
Enables the long term expansion of embryonic stem cells (ESC) without the addition of MEF, LIF, and FBS while retaining pluripotency. ESC's treated with ID-8 in a serum-free medium consistently differentiated into many cell types, including neurons, muscle cells and hepatocytes. Stimulates proliferation at a steady rate. | [General Description]
ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). | [Biochem/physiol Actions]
ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period). | [storage]
+4°C | [References]
1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242
2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18 |
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| Company Name: |
LETOPHARM LIMITED
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+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
SPIRO PHARMA
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| Telephone: |
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| Website: |
www.spiropharma.com.cn |
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