| Identification | Back Directory | [Name]
AC-LEU-VAL-LYS-ALDEHYDE | [CAS]
147600-40-6 | [Synonyms]
AC-LVK-CHO
AC-LEU-VAL-L-LYSINAL
AC-LEU-VAL-LYS-ALDEHYDE
CATHEPSIN B INHIBITOR II
L-Valinamide, N-acetyl-L-leucyl-N-[(1S)-5-amino-1-formylpentyl]- | [Molecular Formula]
C19H36N4O4 | [MDL Number]
MFCD00237496 | [MOL File]
147600-40-6.mol | [Molecular Weight]
384.51 |
| Chemical Properties | Back Directory | [Boiling point ]
665.5±55.0 °C(Predicted) | [density ]
1.059±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
water: 1 mg/mL | [form ]
solid | [pka]
13.43±0.46(Predicted) | [color ]
white | [Water Solubility ]
water: 1mg/mL | [Sequence]
Ac-Leu-Val-{Lys-Aldehyde} |
| Hazard Information | Back Directory | [Uses]
Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1]. | [Biological Activity]
Cell permeable: no''Primary Target
cathepsin B''Product does not compete with ATP.''Reversible: no''Target IC50: 4 nM against cathepsin B | [IC 50]
Cathepsin B: 4 nM (IC50) | [References]
[1] McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9. DOI:10.1021/jm00060a016
[2] Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702. DOI:10.1371/journal.pone.0075702 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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