| Identification | Back Directory | [Name]
EPQ-PY-EEIPIYL* | [CAS]
147612-86-0 | [Synonyms]
(pY)EEI
YEEI PEPTIDE
EPQ-PY-EEIPIYL*
SH2 DOMAIN LIGAND (2)
GLU-PRO-GLN-PTYR-GLU-GLU-ILE-PRO-ILE-TYR-LEU
H-GLU-PRO-GLN-PTYR-GLU-GLU-ILE-PRO-ILE-TYR-LEU-OH
YEEI Peptide, Phosphorylated trifluoroacetate salt
GLU-PRO-GLN-TYR(PO3H2)-GLU-GLU-ILE-PRO-ILE-TYR-LEU
H-GLU-PRO-GLN-TYR(H2PO3)-GLU-GLU-ILE-PRO-ILE-TYR-LEU-OH
H-GLU-PRO-GLN-TYR(PO3H2)-GLU-GLU-ILE-PRO-ILE-TYR-LEU-OH
L-Leucine, L-α-glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-isoleucyl-L-tyrosyl- | [Molecular Formula]
C66H97N12O24P | [MDL Number]
MFCD00798253 | [MOL File]
147612-86-0.mol | [Molecular Weight]
1473.52 |
| Chemical Properties | Back Directory | [storage temp. ]
-15°C
| [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water : 2 mg/mL (1.36 mM; ultrasonic and adjust pH to 2 with HCl) |
| Hazard Information | Back Directory | [Uses]
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains[1][2]. | [storage]
Store at -20°C | [References]
[1] G Payne, et al. The phosphopeptide-binding specificity of Src family SH2 domains. Chem Biol. 1994 Oct;1(2):99-105. DOI:10.1016/1074-5521(94)90047-7
[2] T D Mulhern, et al. The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure. 1997 Oct 15;5(10):1313-23. DOI:10.1016/s0969-2126(97)00283-9 |
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