| Identification | Back Directory | [Name]
bis-PEG2-endo-BCN | [CAS]
1476737-97-9 | [Synonyms]
bis-PEG2-endo-BCN
endo-BCN-PEG2-endo-BCN
5,8-Dioxa-2,11-diazadodecanedioic acid, 1,12-bis[(1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl] ester, rel- | [Molecular Formula]
C28H40N2O6 | [MDL Number]
MFCD30527399 | [MOL File]
1476737-97-9.mol | [Molecular Weight]
500.63 |
| Chemical Properties | Back Directory | [Boiling point ]
668.3±45.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Oil | [pka]
11.75±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
bis-PEG2-endo-BCN is a click chemistry reagent, The BCN group enable copper free click chemitry with azide-tagged molecules. | [Uses]
bis-PEG2-endo-BCN is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. bis-PEG2-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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