| Identification | Back Directory | [Name]
HIV (GP120) FRAGMENT (318-327) | [CAS]
147841-68-7 | [Synonyms]
I-10, P18IIIB I10
HIV (GP120) (318-327)
HIV (GP120) FRAGMENT (318-327)
ARG-GLY-PRO-GLY-ARG-ALA-PHE-VAL-THR-ILE
H-ARG-GLY-PRO-GLY-ARG-ALA-PHE-VAL-THR-ILE-OH
LYS-ALA-ARG-VAL-NLE-PHE: NO2-GLU-ALA-NLE-NH2 [KARV-NLE-F: NO2-EA-NLE-NH2] | [Molecular Formula]
C48H80N16O12 | [MDL Number]
MFCD00672432 | [MOL File]
147841-68-7.mol | [Molecular Weight]
1073.25 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [pka]
3.36±0.10(Predicted) | [Sequence]
Arg-Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile | [InChIKey]
OPTVPTKXPSEPBD-JLHVISHLSA-N |
| Hazard Information | Back Directory | [Uses]
HIV gp120 (318-327) is a short sequence of the HIV-1 strain IIIB envelope peptide (rgpgrafvti) that corresponds to the conserved C-terminal region of the glycoprotein. HIV gp120 (318-327) is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIV gp120 (318-327) lacks the A2 anchor residues recognized by epitope-specific CTLs but has structural features that confer promiscuous A2 binding[1][2]. | [References]
[1] Kmieciak D, et al. The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis. J Immunol. 1998 Jun 1;160(11):5676-83. PMID:9605175
[2] Gu L, et al. A recombinant adenovirus-based vector elicits a specific humoral immune response against the V3 loop of HIV-1 gp120 in mice through the "Antigen Capsid-Incorporation" strategy. Virol J. 2014 Jun 16;11:112. DOI:10.1186/1743-422X-11-112 |
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