| Identification | Back Directory | [Name]
3-Morpholinone, 6-[2-(9H-carbazol-4-yloxy)ethyl]-4-[2-(2-methoxyphenoxy)ethyl]- | [CAS]
1479049-35-8 | [Synonyms]
Homo-V-II-36
3-Morpholinone, 6-[2-(9H-carbazol-4-yloxy)ethyl]-4-[2-(2-methoxyphenoxy)ethyl]- | [Molecular Formula]
C27H28N2O5 | [MOL File]
1479049-35-8.mol | [Molecular Weight]
460.52 |
| Chemical Properties | Back Directory | [Boiling point ]
703.8±60.0 °C(Predicted) | [density ]
1.252±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
16.60±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Homo-VK-II-36 is a carvedilol analogue. It acts by inhibiting store-?overload-?induced calcium release (SOICR) through the RyR2 channel. | [Uses]
SOICR-IN-1 (compound 32) is a store-overload induced calcium release (SOICR) inhibitor with an IC50 value of 14.6 μM. SOICR-IN-1 can be used for the research of cardiac arrhythmias[1]. | [References]
[1] Smith CD, et al. Novel carvedilol analogues that suppress store-overload-induced Ca2+ release. J Med Chem. 2013 Nov 14;56(21):8626-55. DOI:10.1021/jm401090a |
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