| Identification | Back Directory | [Name]
Trovirdine (Hydrochloride) | [CAS]
148311-89-1 | [Synonyms]
LY 300082
LY-300082
LY 300046 hydrochloride
Trovirdine (Hydrochloride)
1-(5-bromopyridin-2-yl)-3-(2-pyridin-2-ylethyl)thiourea:hydrochloride | [Molecular Formula]
C13H14BrClN4S | [MDL Number]
MFCD00920103 | [MOL File]
148311-89-1.mol | [Molecular Weight]
373.699 |
| Hazard Information | Back Directory | [Uses]
Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells[1]. | [References]
[1] STRUCTURE-BASED DESIGN OF N-[2-(1-PIPERIDINYLETHYL)]-N'-[2-(5- BROMOPYRIDYL)]-THIOUREA AND N-[2-(1-PIPERAZINYLETHYL)]-N'-[2- (5-BROMOPYRIDYL)]-THIOUREA AS POTENT NON-NUCLEOSIDE INHIBITORS OF HIV-1 REVERSE TRANSCRIPTASE |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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