| Identification | Back Directory | [Name]
Fradafiban | [CAS]
148396-36-5 | [Synonyms]
BIBU-52
Fradafiban
3-Pyrrolidineacetic acid, 5-[[[4'-(aminoiminomethyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-2-oxo-, (3S,5S)- | [Molecular Formula]
C20H21N3O4 | [MDL Number]
MFCD00919205 | [MOL File]
148396-36-5.mol | [Molecular Weight]
367.4 |
| Hazard Information | Back Directory | [Uses]
Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. | [Definition]
ChEBI: A pyrrolidinone that is pyrrolidin-2-one which is substituted at positions 3 and 5 by carboxymethyl and hydroxymethyl groups, respectively, and in which the hydrogen of the resulting alcoholic hydroxy group is replaced by a 4'-carbamimidoylbiphenyl-4-yl gr
up (the S,S-diastereoisomer). A figrinogen receptor antagonist. | [in vivo]
Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion[1]. | [References]
[1] Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8. DOI:10.1161/01.cir.96.4.1130 |
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