| Identification | Back Directory | [Name]
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER | [CAS]
148451-96-1 | [Synonyms]
L732138
L-732,138
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER
N-acetyl-L-tryptophan 3,5-bis*(trifluoromethyl)be
3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan
N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROM ETHYL)BENZ
N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROMETHYL)-BENZYL ESTER
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester,L-732,138
L-Tryptophan, N-acetyl-, [3,5-bis(trifluoromethyl)phenyl]methyl ester
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester >=99% (TLC), powder
[3,5-Bis(Trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-Indol-3-Yl)propanoate | [Molecular Formula]
C22H18F6N2O3 | [MDL Number]
MFCD00237267 | [MOL File]
148451-96-1.mol | [Molecular Weight]
472.38 |
| Chemical Properties | Back Directory | [Melting point ]
147-148 °C(lit.)
| [Boiling point ]
554.1±50.0 °C(Predicted) | [density ]
1.396±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Soluble to 100 mM in ethanol and to 100 mM in DMSO | [form ]
powder
| [pka]
14.63±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
L-732,138 is a Substance P (SP) receptor antagonist. | [Biological Activity]
Potent and highly selective competitive tachykinin NK 1 receptor antagonist (IC 50 = 2.3 nM). | [in vivo]
L-732138 (10-4-10-2 mol/kg; intravenous injection; for 15 minutes; male Dunkin-Hartley guinea-pigs) treatment abolishes vagally-induced plasma exudation and significantly inhibits the enhancement by LPS. The LPS-enhanced vagally-induced plasma exudation is not completely inhibited by either L-732138 or SOD pretreatment alone, but is blocked by the combination of both pretreatments[3]. | Animal Model: | Male Dunkin-Hartley guinea-pigs (350-500 g) injected with lipopolysaccharide (LPS)[3] | | Dosage: | 10-4 mol/kg , 10-3 mol/kg and 10-2 mol/kg | | Administration: | Intravenous injection; for 15 minutes | | Result: | Abolished the vagally-induced plasma leakage in tracheobronchial tissues, and dose-dependently inhibited the LPS enhanced vagally-induced plasma exudation in traceobronchial tissues.
|
| [IC 50]
NK1: 2.3 nM (IC50) | [storage]
Store at RT |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|