| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Water: 1 mg/ml | [form ]
A lyophilized powder | [color ]
White to off-white | [Water Solubility ]
Water: 100 mg/mL | [Sequence]
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1]. | [Definition]
ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+). | [IC 50]
NK1; Human Endogenous Metabolite | [storage]
Store at -20°C | [References]
[1] Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24. DOI:10.1091/mbc.6.5.509
[2] Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527. DOI:10.1111/cpr.12527 |
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