| Identification | Back Directory | [Name]
MOPIPP | [CAS]
1485521-76-3 | [Synonyms]
MOPIPP
2-Propen-1-one, 3-(5-methoxy-2-propyl-1H-indol-3-yl)-1-(4-pyridinyl)-, (2E)- | [Molecular Formula]
C20H20N2O2 | [MDL Number]
MFCD32063578 | [MOL File]
1485521-76-3.mol | [Molecular Weight]
320.39 |
| Hazard Information | Back Directory | [Uses]
MOPIPP is a novel indolebased chalcone, and vacuolin-1, is a non-lethal vacuoleinducing 2-propyl analog of MOMIPP.html" class="link-product" target="_blank">MOMIPP (HY-119624). MOPIPP induces cellular vacuolization and increases autophagosomes numbers. MOPIPP also triggers methuosis, and interrupts glucose uptake and glycolytic metabolism. MOPIPP can cross the blood-brain barrier and shows efficacy in suppressing tumor progression agaisnt glioblastoma cells[1][2][3]. | [in vivo]
MOMIPP (80 mg/kg; i.p.; single dose) readily penetrates the bloodbrain barrier in female Swiss Webster Mice and (80 mg/kg; i.p.; every 24 h; 15 d) is effective in suppressing progression of intracerebral glioblastoma xenografts in female NCR-Foxn1 mice[3].
| Animal Model: | Intracerebral xenograft model in NCR-Foxn1 mice (female, 7-8 weeks, injected with U251- LUC cells)[3] | | Dosage: | 80 mg/kg | | Administration: | Intraperitoneal injection; every 24 hours for 15 days; monitored tumor progression by BLI on the days 7, 11, 15 | | Result: | Significantly inhibited tumor progression. |
| [References]
[1] Mbah NE, et al. Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones. Cell Biol Toxicol. 2017 Jun;33(3):263-282. DOI:10.1007/s10565-016-9369-2
[2] Li Z, et al. Vacuole-inducing compounds that disrupt endolysosomal trafficking stimulate production of exosomes by glioblastoma cells. Mol Cell Biochem. 2018 Feb;439(1-2):1-9. DOI:10.1007/s11010-017-3130-x
[3] Li Z, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77. DOI:10.1186/s12885-019-5288-y |
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