| Identification | Back Directory | [Name]
[3,3'-Bipyridine]-5-carboxamide, N-[4-(trifluoromethoxy)phenyl]- | [CAS]
1488090-21-6 | [Synonyms]
BCR-ABL1-IN-1
[3,3'-Bipyridine]-5-carboxamide, N-[4-(trifluoromethoxy)phenyl]- | [Molecular Formula]
C18H12F3N3O2 | [MOL File]
1488090-21-6.mol | [Molecular Weight]
359.3 |
| Chemical Properties | Back Directory | [Boiling point ]
423.7±45.0 °C(Predicted) | [density ]
1.379±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.96±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BCR-ABL1-IN-1 is a potent, orally active, and specific inhibitor of ABL kinase. BCR-ABL1-IN-1 has potential for elucidating the role of ABL kinases in the brain in non-clinical studies[1]. | [References]
[1] Manley PW, et al. A kinase inhibitor which specifically targets the ABL myristate pocket (STAMP), but unlike asciminib crosses the blood-brain barrier. Bioorg Med Chem Lett. 2022;59:128577. DOI:10.1016/j.bmcl.2022.128577 |
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