| Identification | Back Directory | [Name]
S-15176 DIFUMARATE SALT | [CAS]
148913-55-7 | [Synonyms]
S-15176 difumarate salt >=98% (HPLC), solid
N-[(3,5-Di-tert-butyl-4-hydroxy-1-thiophenyl)]-3-propyl-Nμ-(2,3,4-trimethoxybenzyl)piperazine difumarate salt | [Molecular Formula]
C31H48N2O4S.2C4H4O4 | [MDL Number]
MFCD11046049 | [MOL File]
148913-55-7.mol | [Molecular Weight]
776.939 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 16 mg/mL, soluble | [form ]
solid | [InChIKey]
ANXPOPNCJIJXJW-LVEZLNDCSA-N | [SMILES]
OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.COc1ccc(CN2CCN(CCCSc3cc(c(O)c(c3)C(C)(C)C)C(C)(C)C)CC2)c(OC)c1OC |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
The protonophoric activity of S-15176 difumarate salt was studied in mitochondria isolated from livers of Wistar rats.5 | [Biological Activity]
Antioxidant and anti-ischemic agent. Also inhibits mitochondrial permeability transitionprevents the early step in apoptosis by preventing collapse of the electrochemical gradient across the mitochondrial membrane. IC50 for in vitro lipid peroxidation is 0.3 μM. IC50 for carnitine palmitoyltransferase (CPT-1) in heart homogenate is 16.8 μM. The shift from fatty acid to glucose oxidation may contribute to anti-ischemic effect.''S-15176 suppresses the mitochondrial permeability transition in response to calcium ions and inorganic phosphate and inhibits the release of cytochrome c in response to silver ions. It exhibits weak protonophoric activity.5 |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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