| Identification | Back Directory | [Name]
Amikacin sulfate salt | [CAS]
149022-22-0 | [Synonyms]
AMIKASIN SULFATE
liusuanamukaxonm
Amikacin sulfate(5:9)
Amikacin sulfate salt
AMIKACIN SULFATE 1:1.8
mikacin disulfate salt
Amikacin sulfate salt USP/EP/BP
AMIKACIN SULFATE SALT, AMINOGLYCOSID
O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine sulfate(5:9)
(2S)-4-AMino-N-{(1R,2S,3S,4R,5S)-5-aMino-2-[(3-aMino-3-deoxy-a-D-glucopyranosyl)oxy]-4-[(6-aMino-6-deoxy-a-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanaMide sulfate (1:2) | [EINECS(EC#)]
254-648-6 | [Molecular Formula]
C22H45N5O17S | [MDL Number]
MFCD23843808 | [MOL File]
149022-22-0.mol | [Molecular Weight]
683.68 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
H2O: soluble50mg/mL | [form ]
solid | [color ]
white to off-white | [biological source]
synthetic | [InChIKey]
HIBICIOPDUTNRR-BOEHXBESSA-N |
| Hazard Information | Back Directory | [Uses]
Amikacin is an aminoglycoside antibiotic commonly used in the treatment of drug-resistant mycobacteria . It is used to study organism-directed delivery of antibiotics as well as drug resistance . | [General Description]
Chemical structure: aminoglycoside | [Biochem/physiol Actions]
Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading. | [in vivo]
Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo[3]. | Animal Model: | Male Fischer 344 rats (40-50-day-old)[3] | | Dosage: | 320?mg/kg | | Administration: | Subcutaneous injection; daily; for 10 days | | Result: | Induced hearing loss in rats.
|
| [IC 50]
Aminoglycoside |
|
|