| Identification | Back Directory | [Name]
1,2,4-Triazine-6-carboxamide, 3-[[(1R,2S)-2-aminocyclohexyl]amino]-5-(1H-indol-7-ylamino)- | [CAS]
1491150-77-6 | [Synonyms]
Syk-IN-1
1,2,4-Triazine-6-carboxamide, 3-[[(1R,2S)-2-aminocyclohexyl]amino]-5-(1H-indol-7-ylamino)- | [Molecular Formula]
C18H22N8O | [MDL Number]
MFCD28411430 | [MOL File]
1491150-77-6.mol | [Molecular Weight]
366.42 |
| Chemical Properties | Back Directory | [Boiling point ]
718.8±70.0 °C(Predicted) | [density ]
1.432±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (272.91 mM) | [form ]
Solid | [pka]
13.17±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Syk-IN-1 (compound 4) is a potent Syk inhibitor, with an IC50 of 35 nM[1]. | [References]
[1] Thoma G, et al. Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg Med Chem Lett. 2015;25(20):4642-4647. DOI:10.1016/j.bmcl.2015.08.037 |
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