| Identification | Back Directory | [Name]
N-(4-(3-(2,4-diamino-6,7-dihydro-5H-cyclopenta(d)pyrimidin-5-yl)propyl)benzoyl)glutamic acid | [CAS]
149325-95-1 | [Synonyms]
DDCPPB-Glu
N-(4-(3-(2,4-diamino-6,7-dihydro-5H-cyclopenta(d)pyrimidin-5-yl)propyl)benzoyl)glutamic acid
L-Glutamic acid, N-[4-[3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)propyl]benzoyl]-
(2S)-2-(4-(3-(2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)propyl)benzamido)pentanedioic acid | [Molecular Formula]
C22H27N5O5 | [MOL File]
149325-95-1.mol | [Molecular Weight]
441.48 |
| Hazard Information | Back Directory | [Description]
DDCPPB-Glu is a 6-5 fused ring heterocycle antifolate that exhibits antitumor activity. | [Uses]
DDCPPB-Glu (compound 3a) is a compound with anti-tumor activity, which has the activity of inhibiting tumor cell growth and prolonging survival. DDCPPB-Glu has growth inhibition effect on various tumor cell lines, can increase the survival time of leukemia mice, and has inhibitory effect on tumors such as colon cancer and lung cancer. | [References]
[1] Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids DOI:10.1021/jm00037a012 |
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