| Identification | Back Directory | [Name]
BM635 | [CAS]
1493762-74-5 | [Synonyms]
BM635
Morpholine, 4-[[1-(4-fluorophenyl)-2-methyl-5-[4-(1-methylethyl)phenyl]-1H-pyrrol-3-yl]methyl]- | [Molecular Formula]
C25H29FN2O | [MDL Number]
MFCD31619277 | [MOL File]
1493762-74-5.mol | [Molecular Weight]
392.51 |
| Chemical Properties | Back Directory | [Boiling point ]
500.3±50.0 °C(Predicted) | [density ]
1.12±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 31 mg/mL (78.98 mM) | [form ]
Solid | [pka]
6.70±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BM 635, is a MmpL3 inhibitor with great anti-mycobacterial activity. | [in vivo]
BM635 has potent MIC (0.12 μM), Tox50:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity, with an ED99 of 49 mg/Kg (IC95%: 43–54 mg/Kg)[1]. The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (Cmax=1.62 μM) and a moderate bioavailability (46%). Its poor aqueous solubility together with its high lipophilicity leads to low exposure in vivo[2]. | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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