| Identification | Back Directory | [Name]
NaV1.7 inhibitor-1 | [CAS]
1494585-79-3 | [Synonyms]
NaV1.7 inhibitor-1
Benzamide, 5-cyclopropyl-N-(cyclopropylsulfonyl)-2-fluoro-4-[(6-methylspiro[2.5]oct-6-yl)methoxy]-
Inhibitor,NaV1.7 inhibitor-1,inhibit,Na channels,NaV1.7 inhibitor1,NaV1.7 inhibitor 1,NaV-1.7 inhibitor-1,Sodium Channel,Na+ channels | [Molecular Formula]
C23H30FNO4S | [MDL Number]
MFCD32067926 | [MOL File]
1494585-79-3.mol | [Molecular Weight]
435.55 |
| Chemical Properties | Back Directory | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.70±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NaV1.7 inhibitor-1 is an efficacious voltage-gated sodium channel (NaV) 1.7 inhibitor with an IC50 of 0.6 nM for hNaV1.7, exhibits 80-fold selectivity versus hNaV1.5[1]. | [IC 50]
h Nav1.7: 0.6 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Sun S, Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-GatedSodium Channel (NaV) 1.7 with Potent Analgesic Activity. J Med Chem. 2019 Jan 24;62(2):908-927. DOI:10.1021/acs.jmedchem.8b01621 |
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