| Identification | Back Directory | [Name]
Cyclohexanecarboxamide, 3-amino-N-1H-indazol-5-yl- | [CAS]
1496088-76-6 | [Synonyms]
SR17398
SR-17398
SR 17398
Cyclohexanecarboxamide, 3-amino-N-1H-indazol-5-yl- | [Molecular Formula]
C14H18N4O | [MOL File]
1496088-76-6.mol | [Molecular Weight]
258.32 |
| Hazard Information | Back Directory | [Description]
SR-17398 is a Unc-51-Like Kinase 1 (ULK1) inhibitor (IC50; 22.4 uM). Small molecule inhibition of ULK1 potentially provides an avenue for suppressing autophagy. Autophagy is protective for cancers experiencing a decrease in nutrient availability or damage caused by cancer therapeutics.9,10 Accordingly, blocking autophagy via small molecule inhibitors in autophagy-reliant cancers could increase the efficacy of current chemotherapeutics and may result in tumor suppression as a standalone chemotherapy. | [Uses]
SR-17398 is an inhibitor for Unc-51-Like Kinase 1 (ULK1) with an IC50 of 22.4 μM[1]. | [IC 50]
ULK1: 22.4 μM (IC50) | [References]
[1] Wood SD, et al., In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors. ACS Med Chem Lett. 2017 Nov 22;8(12):1258-1263. DOI:10.1021/acsmedchemlett.7b00344 |
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