| Identification | Back Directory | [Name]
leptolstatin | [CAS]
149633-91-0 | [Synonyms]
leptolstatin
2H-Pyran-2-one, 6-[(1E,3Z,5R,7E,9E,11R,13S,14R,15S,17E)-14,19-dihydroxy-3,5,9,11,13,15,17-heptamethyl-12-oxo-1,3,7,9,17-nonadecapentaen-1-yl]-5,6-dihydro-, (6R)- | [Molecular Formula]
C31H46O5 | [MOL File]
149633-91-0.mol | [Molecular Weight]
498.69 |
| Hazard Information | Back Directory | [Description]
Leptolstatin is a gap phase-specific inhibitor. | [Uses]
Leptolstatin is an inhibitor of the progression of G1 and G2 phases of the mammalian cell cycle. Leptolstatin can be extracted from the fermentation broth of Streptomyces sp. SAM1595[1]. | [References]
[1] Abe K, et al. Leptolstatin from Streptomyces sp. SAM1595, a new gap phase-specific inhibitor of the mammalian cell cycle. I. Screening, taxonomy, purification and biological activities. J Antibiot (Tokyo). 1993 May;46(5):728-34. DOI:10.7164/antibiotics.46.728 |
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