| Identification | Back Directory | [Name]
Ethanaminium, N,N,N-trimethyl-2-[[(4-methylphenyl)methyl]sulfonyl]-, iodide (1:1) | [CAS]
1496553-39-9 | [Synonyms]
SMA12b
SMA-12b
SMA 12b
Ethanaminium, N,N,N-trimethyl-2-[[(4-methylphenyl)methyl]sulfonyl]-, iodide (1:1) | [Molecular Formula]
C13H22INO2S | [MOL File]
1496553-39-9.mol | [Molecular Weight]
383.29 |
| Hazard Information | Back Directory | [Description]
SMA-12b is an inhibitor of IL-1. | [Uses]
SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases[1]. | [References]
[1] Rzepecka J, et al. Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome[J]. Journal of autoimmunity, 2015, 60: 59-73. DOI:10.1016/j.jaut.2015.04.005 |
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