| Identification | Back Directory | [Name]
VAL-BORO-PRO | [CAS]
149682-77-9 | [Synonyms]
Pt 100
TALABOSTA
talabostat
VAL-BORO-PRO
Unii-kz1o2sh88z
Talabostat (PT100)
Talabostat (Val-boroPro, PT-100)
PT-100;VALBOROPRO;VAL-BOROPRO;PT100;PT 100
[(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid
[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid
Boronic acid, ((2R)-1-((2S)-2-amino-3-methyl-1-oxobutyl)-2-pyrrolidinyl)-
Boronic acid, (1-(2-amino-3-methyl-1-oxobutyl)-2-pyrrolidinyl)-, (R-(R*,S*))-
Talabostat/ Boronic acid, [(2R)-1-[(2S)-2-aMino-3-Methyl-1-oxobutyl]-2-pyrrolidinyl]- | [Molecular Formula]
C9H19BN2O3 | [MOL File]
149682-77-9.mol | [Molecular Weight]
214.07 |
| Chemical Properties | Back Directory | [Boiling point ]
421.4±55.0 °C(Predicted) | [density ]
1.15 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 40 mg/mL (186.85 mM) | [pka]
9.71±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Treatment of cancer; hematopoietic stimulant. | [in vivo]
Talabostat (Val-boroPro; PT100) can stimulate immune responses against tumors involving both the innate and adaptive branches of the immune system.In WEHI 164 fibrosarcoma and EL4 and A20/2J lymphoma models, Talabostat (Val-boroPro) causes regression and rejection of tumors. The antitumor effect appears to involve tumor-specific CTL and protective immunological memory.Talabostat (Val-boroPro) treatment of WEHI 164-inoculated mice increases mRNA expression of cytokines and chemokines known to promote T-cell priming and chemoattraction of T cells and innate effector cells[4]. | [IC 50]
DPP-4 | [storage]
Store at -20°C |
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