| Identification | Back Directory | [Name]
LOE 908 HYDROCHLORIDE | [CAS]
149759-26-2 | [Synonyms]
LOE 908
Pinokalant
LOE 908 HYDROCHLORIDE
1-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-
3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamidehydrochloride | [Molecular Formula]
C41H48N2O9 | [MDL Number]
MFCD09038554 | [MOL File]
149759-26-2.mol | [Molecular Weight]
712.83 |
| Chemical Properties | Back Directory | [Boiling point ]
803.7±65.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [form ]
Solid | [pka]
5.47±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
LOE 908 Hydrochloride is a isoquinoline derivative and a cation channel blocker. LOE 908 Hydrochloride is a neuroprotective agent. | [Biological Activity]
Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na + and K + channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion. | [in vivo]
Pinokalant significantly reduces cortical infarct volume from 33.8 mm3 to 24.5 mm3[1]. |
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