| Hazard Information | Back Directory | [Description]
QQN-00358 is a novel potent and selective tankyrase (TNKS) inhibitor. | [Uses]
TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1]. | [References]
[1] Qin D,et al. Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors. ACS Med Chem Lett. 2021 May 13;12(6):1005-1010. DOI:10.1021/acsmedchemlett.1c00160 |
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