| Identification | Back Directory | [Name]
3-Isoquinolinecarboxylicacid, decahydro-6-[2-(2H-tetrazol-5-yl)ethyl]-, (3R,4aS,6S,8aS)-rel- | [CAS]
150010-68-7 | [Synonyms]
LY215490
LY-215490
LY-293559
LY 215490
3-Isoquinolinecarboxylicacid, decahydro-6-[2-(2H-tetrazol-5-yl)ethyl]-, (3R,4aS,6S,8aS)-rel- | [Molecular Formula]
C13H21N5O2 | [MDL Number]
MFCD00920887 | [MOL File]
150010-68-7.mol | [Molecular Weight]
279.34 |
| Hazard Information | Back Directory | [Description]
LY 215490 is a novel, selective, competitive and systemically active AMPA receptor antagonist. It is a neuroprotective agent against focal ischaemia in a model of permanent MCA occlusion in the rat. | [Uses]
LY 215490 is a selective, competitive AMPA receptor antagonist against AMPA, CGSl9755 and kainate with IC50 values of 4.8, 26.4 and 247 μM, respectively. LY 215490 shows neuroprotective effects in focal ischaemia[1]. | [References]
[1] Gill R, et al. The neuroprotective effects of the decahydroisoquinoline, LY 215490; a novel AMPA antagonist in focal ischaemia. Neuropharmacology. 1994 Dec;33(12):1529-36. DOI:10.1016/0028-3908(94)90126-0
[2] Ornstein PL, et al. (3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist. J Med Chem. 1993 Jul 9;36(14):2046-8. DOI:10.1021/jm00066a016 |
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