| Identification | Back Directory | [Name]
Piperidine, 1-(3-phenoxypropyl)-4-(phenylmethyl)- | [CAS]
150085-21-5 | [Synonyms]
S1R agonist2
Piperidine, 1-(3-phenoxypropyl)-4-(phenylmethyl)- | [Molecular Formula]
C21H27NO | [MOL File]
150085-21-5.mol | [Molecular Weight]
309.45 |
| Chemical Properties | Back Directory | [Boiling point ]
446.4±28.0 °C(Predicted) | [density ]
1.037±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
9.70±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1]. | [in vivo]
S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) does not induce embryo death (100% of embryos alive) at 10 μM, but induces the death of all zebrafish embryo at the highest dose tested (50 μM)[1]. | [IC 50]
Sigma 1 Receptor: 1.1 nM (Ki); Sigma 2 Receptor: 88 nM (Ki) | [References]
[1] Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163. DOI:10.1016/j.ejmech.2023.115163 |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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