| Identification | Back Directory | [Name]
Urea, N-[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]-N'-[3-(trifluoromethyl)phenyl]- | [CAS]
1501618-04-7 | [Synonyms]
EIF2α activator 2
Urea, N-[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]-N'-[3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C21H20F6N2O2 | [MOL File]
1501618-04-7.mol | [Molecular Weight]
446.39 |
| Chemical Properties | Back Directory | [Boiling point ]
465.4±45.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [solubility ]
Acetonitrile: Soluble | [form ]
Solid | [pka]
13.18±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1]. | [References]
[1] Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501. DOI:10.1016/j.ejmech.2022.114501 |
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