| Identification | Back Directory | [Name]
H-DL-ISOSER-PHE-LEU-LEU-ARG-ASN-OH | [CAS]
150242-29-8 | [Synonyms]
ISO-TRAP
DL-ISOSER-PHE-LEU-LEU-ARG-ASN
H-DL-ISOSER-PHE-LEU-LEU-ARG-ASN-OH
(DL-Isoser1)-TRAP-6 trifluoroacetate salt
L-Asparagine, 2-hydroxy-β-alanyl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl- (9CI)
L-Asparagine,N2-[N2-[N-[N-[N-(2-hydroxy-β-alanyl)-L-phenylalanyl]-L-leucyl]-L-leucyl]-L-arginyl]-
iso-TRAP, (DL-Isoser1)-PAR-1 (1-6) (huMan), (DL-Isoser1)-Proteinase Activated Receptor 1 (1-6) (huMan), (DL-Isoser1)-ThroMbin Receptor 1 (1-6) (huMan), (DL-Isoser1)-ThroMbin Receptor Activator Peptide 6, (DL-Isoser1)-Coagulation Factor II Receptor (1-6) (huMan) | [Molecular Formula]
C34H56N10O9 | [MDL Number]
MFCD00237283 | [MOL File]
150242-29-8.mol | [Molecular Weight]
748.87 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [form ]
Solid | [pka]
3.17±0.10(Predicted) | [color ]
White to off-white | [Sequence]
{DL-Isoser}-Phe-Leu-Leu-Arg-Asn |
| Hazard Information | Back Directory | [Uses]
iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets. iso-TRAP-6 is an analog of TRAP-6 (HY-P0078) that refers to the use of isoserine instead of serine as first amino acid[1]. | [IC 50]
PAR1 | [References]
[1] Gremmel T, et, al. Sex-specific platelet activation through protease-activated receptor-1 in patients undergoing cardiac catheterization. Atherosclerosis. 2021 Dec;339:12-19. DOI:10.1016/j.atherosclerosis.2021.11.011 |
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