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Relebactam sodium (MK-7655 sodium) is a potent and selective β-lactamase inhibitor with the activity of delaying the development of bacterial resistance to antibiotics. Relebactam sodium can bind to a variety of β-lactamases, thereby improving the efficacy of β-lactam antibiotics. Relebactam sodium shows good application potential in inhibiting complicated bacterial infections[1]. | [References]
[1] Lapuebla A, et al. Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City. Antimicrob Agents Chemother. 2015 Aug;59(8):5029-31. DOI:10.1128/AAC.00830-15
[2] Imipenem monohydrate/cilastatin sodium/relebactam monohydrate, pretomanid, and elexacaftor/tezacaftor/ivacaftor DOI:10.1016/j.japh.2020.01.027
[3] Bush K. A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens. Int J Antimicrob Agents. 2015 Nov;46(5):483-93. DOI:10.1016/j.ijantimicag.2015.08.011 |
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