| Identification | Back Directory | [Name]
(S)-N-4-BOC-N-1-CBZ-2-PIPERAZINE CARBOXYLIC ACID
| [CAS]
150407-69-5 | [Synonyms]
S-1-cbz-4-Boc-2-piperazinecarboxylate
(S)-N-4-Boc-N-1-Cbz-2-Piperazinecarboxylic acid
(S)-Piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester
(2S)-1-[(benzyloxy)carbonyl]-4-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid
1,2,4-Piperazinetricarboxylic acid, 4-(1,1-diMethylethyl) 1-(phenylMethyl) ester, (2S)- | [Molecular Formula]
C18H24N2O6 | [MDL Number]
MFCD07369991 | [MOL File]
150407-69-5.mol | [Molecular Weight]
364.39 |
| Hazard Information | Back Directory | [Synthesis]
To a solution of 1-tert-butyl piperazine-1,3-dicarboxylate (4.5 g, 19.565 mmol, 1.0 eq.) in dichloromethane (DCM, 125 mL) were sequentially added triethylamine (TEA, 5.93 g, 58.70 mmol, 3.0 eq.) and benzyl chloroformate (CbzCl, 5 g, 29.35 mmol, 3.0 eq.). The reaction mixture was stirred at room temperature for 4 h, during which the reaction progress was monitored by liquid chromatography-mass spectrometry (LC-MS) and thin layer chromatography (TLC). Upon completion of the reaction, the mixture was concentrated and the resulting residue was purified by silica gel column chromatography (eluent ratio: petroleum ether/ethyl acetate = 5/1) to afford the target product (S)-1-((benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (5 g, 70% yield) as a white solid. | [References]
[1] Patent: WO2017/98328, 2017, A2. Location in patent: Paragraph 00276 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
BePharm Ltd
|
| Telephone: |
400-685-9117 |
| Website: |
www.bepharm.com |
|